Description
Product Characteristics: The R1-2 monoclonal antibody reacts with mouse CD49d, a 150kD glycoprotein member of the integrin family. CD49d is also known as integrin alpha4 (ITGA4). Together with integrin beta1 (CD29), CD49d forms the VLA-4 heterodimer that serves as a receptor for fibronectin and VCAM-1. VLA-4 is widely expressed on lymphocytes, monocytes, thymocytes, and NK cells. CD49d can dimerize with integrin beta7 to form a receptor that binds the mucosal vascular addressin molecule, MAdCAM-1.
Target Information: The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008]